inflammation

Serotonin Robbers

By Nicolette Francey Asselin, M.D

1. Sparkless Days

Happiness determines how long we live and how strong our families are.

After returning from an overseas trip, I was fighting time changes and a cold that robbed me of hours of sleep. The day ahead appeared blurred, faint, colorless, and gray. The natural sparkle that generated my sense of enthusiasm and fired my first steps out of bed, had vanished. Later, I sat down to my favorite routine, writing, but chapters I had written appeared dull, unexciting, and soporific. The sunless day weighed heavily on me, or even spicy food seemed bland, vapid, and savorless. Why such a low mood? My husband and I had just had a pleasant visit with my family in Europe, and no dark clouds were lurking on the horizon of our peaceful lives. Full story

This story is the first of a 4 part article series:

  • 1. Sparkless Days
  • 2. Portrait of the Robbers
  • 3. Tryptophan Deprivation
  • 4. Manufacturing the “Magic Powder”

This article can be followed in ReFlex-ions.

Nanoparticles and more…

Nanoparticle Delivery Approach Targets Atherosclerotic Plaques

Tracy Hampton, PhD
JAMA. 2015;313(13):1305. doi:10.1001/jama.2015.2440.
s_jla150008faA promising new strategy against atherosclerosis uses nanoparticles to deliver a peptide fragment of annexin A1 (Ac2-26), a glucocorticoid-regulated protein that helps resolve inflammation, to arterial plaques (Fredman G et al. Sci Transl Med. 2015;7[275]:275ra20). The nanoparticles loaded with Ac2-26 are coated with peptides that target atherosclerotic lesions by binding to type IV collagen, a component of the basement membrane that becomes exposed at sites of vascular injury. Cont